Naveen Jain on the Human Ecosystem and Personalized Optimization of Your Gut Health

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Katie: Hey and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here immediately with my pal, Naveen, who’s an intensely curious entrepreneur who has been taking up some massive, audacious concepts to push humanity ahead. He’s the creator of the award-winning guide “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Categorical, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.

And his present work is in Viome Life Sciences, which was based in 2016 with a mission of creating sickness optionally available by predicting and stopping continual illness via a deeper understanding of a person’s biology at a molecular degree. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to stop and reverse continual illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Artistic Individual by Quick Firm, Prime 20 Entrepreneurs, and lots of extra.

On this episode, we speak in regards to the human ecosystem and personalised optimization of your intestine well being and your general well being. We speak in regards to the purpose the intestine impacts all the physique. Why it’s not simply genetics from our dad and mom however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at start and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.

The distinction between DNA and gene expression. How some meals may be good for some individuals and never others, and methods to know which is greatest for you, but additionally, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The actual purpose it’s vital to chew your meals rather well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, plenty of hyperlinks to study extra within the present notes at wellnessmama.fm, so examine these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.

Naveen: Properly, Katie, so good to see you lastly after a protracted, very long time.

Katie: I’m so excited we get to have a dialog and get to file it and share it immediately, and we’re gonna speak loads about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one particular person I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply speak about this as a result of I believe you’re my solely hobbyist Moon rock collector.

Naveen: Properly, I believe, Katie, you understand, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a manner of expressing that there’s nothing that’s unattainable for us to do. Although it’s known as “Moonshots” that folks thought was tough, if not unattainable to do and having, you understand, now to have the ability to go to the Moon and to me, the gathering of house rocks really was simply merely a passion of capable of maintain one thing in your hand. That could be even earlier than the start of our planet. And it provides you some thought of how fragile we’re that if we don’t handle ourselves, our planet, we as humanity might not survive. As a species, we might not survive.

So, you understand, thought of when somebody says, “I’m actually frightened about our planet,” ask the planet and planet will let you know, “Don’t you are concerned about me as a result of we…” Planet will do exactly fantastic however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing outdoors us goes fallacious, we as inside ecosystem can even be impacted, proper. And that’s coming right down to, you understand, in case you have a look at what’s above, so under is absolutely what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.

Katie: I like that you simply mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you understand him as nicely. And I requested him that query. You already know, your technology’s gonna face loads within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re really asking the fallacious query as a result of the…”

Naveen: Oh, I find it irresistible, I find it irresistible.

Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we must be asking how we may be extra synergistic inside an surroundings that’s larger than us.”

Naveen: That’s the excellent reply. That’s precisely how I might see it that…you understand, when individuals say, “Aren’t you frightened in regards to the planet?” I say, “That’s not the query you have to be asking.” It’s, “Are we frightened in regards to the human species?” That’s what we must be asking.

Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not frightened about however working to unravel. My listeners are fairly well being savvy and perceive or at the very least have a passing understanding that intestine well being impacts the entire total physique. However I really feel like this idea is…nicely, we’ve recognized features of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of firms like Viome, now we have many extra tangible instruments to truly perceive and begin to do one thing about that. However to start out broad, type of give us an outline of what we imply by the well being of the intestine impacts the well being of the entire physique.

Naveen: So, nicely, to begin with, you understand, let’s simply begin from the start. We as human beings will not be merely a product of the DNA from our mother and pop. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which are really expressed in our human physique will not be our personal. They arrive from these microbes which are in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we have a look at the human beings as such by way of all of the genes which are expressed that makes us who we’re, they don’t seem to be people. They’re principally microbial. We’re residing of their world. They don’t stay in our world, proper.

So, once we perceive that, you understand, though you could possibly argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you could possibly argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and comfy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t understand, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Which means it’s to create the ecosystem inside us.

Now think about what nature is telling us, that we simply created a offspring and one of the simplest ways to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes via the start canal, that is the primary publicity the infant will get to the entire world of microbiome. It will get…fully inhales the microbiome because the child’s going via start canal. And sadly, a few of the moms for apparent causes find yourself getting a C-section. They really…the infants will not be going via the identical…they’re uncovered to pores and skin microbiome relatively via the start canal, the microbiome that they’d get via the start canal. And that could be a essentially…the infant, when it’s born, is definitely…the character has created in a manner that the microbes get launched into the infant on the time of the start and that truly now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.

And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the basic half that folks want to know. Seventy p.c of our immune system is alongside our intestine lining. The truth is, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a pal and what’s a foe, proper. So, in some sense, in case you have a look at the human physique, there’s a tube that goes via us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definitely begin to have a look at all alongside the strains there’s a large quantity of microbial existence there. They usually in reality are continuously interacting with our immune system and the immune system is now understanding when there’s really a pathogen that’s coming via the meals or the pathogen that’s coming via the surface world, methods to react to it. And these microbes are the primary sign that tells the immune methods, “This isn’t good. Go do one thing about it, proper.”

And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we lower our pores and skin or whether or not there’s some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are continuously in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique will not be relaxed, you get illness which we name illness.

Katie: Yeah, so many vital factors you simply mentioned to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you mentioned you might be what you eat nevertheless it goes to this point past that. It’s not even you might be what you eat and even you might be what you eat-eat, however what your intestine micro organism eats and the way it grows. And I like that you simply introduced up the start canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the infant, as a result of such as you mentioned, in case you don’t…the infant is of course meant to seed their intestine via the start canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which are in that room, every kind of issues. And we all know that this intestine micro organism at start, an increasing number of we study, units you up in your entire life. But additionally, the excellent news is…and I do know that Viome does lots of analysis on this. All will not be misplaced in case you don’t get an ideal begin. We now have the power to type of get a snapshot and look within the intestine in a very distinctive manner after which optimize to enhance somebody’s well being going ahead.

And likewise, such as you mentioned, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal manner and simply take away the issues which are preserving the physique from being wholesome or perhaps typically give it little additional vitamins to assist get there. Speak a bit bit in regards to the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair many years in the past, and now now we have such wonderful information from this.

Naveen: Properly, it’s very fascinating is this concept of, you understand…in case you return and have a look at couple of many years in the past, it was really the micro organism and all these organisms had been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as rapidly as potential as a result of they will’t presumably be there for our good, proper. And as we began to study extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re imagined to be there and so they in reality…once we feed them issues like, you understand…in olden days, once we had been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these had been all of the vitamins that our physique wanted.

The truth is, in case you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, in case you actually take into consideration all of the issues which are being accomplished within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a despair or nervousness or, you understand, you possibly can name them any names you need, you understand, a lot of these items together with autism is now linked immediately into the intestine microbiome. The truth is, they’ve accomplished now the analysis the place they did merely a microbial transplant known as a fecal transplant and so they had been capable of in reality present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They had been capable of present once you took an individual that has a despair a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve accomplished them in mice and so they’ve accomplished that in reality in people, and clearly, it was accomplished by mistake however that’s really the way it occurred.

The truth is, what’s actually fascinating is habit. They usually’ve proven the identical factor. They took…there have been 17 individuals on the analysis that had been fully hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who really had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind by way of what to do. That’s what the habit is, proper. And I believe that’s actually phenomenal.

And now what we’re studying is each kind of most cancers…in reality what they’ve now checked out is each single stable tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide except it’s there to idiot our immune system into considering that is self and protects the tumor in opposition to the immune system attacking, proper?

Now, think about what…one other factor that’s most fascinating I discovered was once you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the folks that immunotherapy didn’t work, they merely had been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome will not be solely there to maintain us wholesome from all of the illnesses immediately we name the totally different names. Coronary heart illnesses, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. The truth is, we are able to now have a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re in a position to have a look at how…what’s occurring in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re each interleukins, we’re the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.

And so, anyway, the purpose I’m attempting to make is that you simply talked about one thing about these micro organism, and I simply need individuals to know the microorganisms will not be simply micro organism. They’re predominantly micro organism however in addition they encompass yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the most important half in reality in case you observed virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And in case you have a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, in reality there are 10 instances extra phages than the micro organism alone. And meaning these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that in reality adjustments how these micro organism behave by way of what features they’re performing.

So once more, what’s actually fascinating is by what organisms are there, won’t ever let you know what’s going on in your physique. The truth is, their features are what makes the distinction. Which means what they’re producing can…is absolutely the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you in all probability know that lots of the individuals like Akkermansia muciniphila. A number of the firms are promoting them as a probiotic with out realizing that Akkermansia may be good for some individuals and in reality it’s the primary purpose for inflicting a number of sclerosis, and it has additionally been immediately linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one particular person and might do one thing actually unhealthy in one other particular person. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different particular person’s physique. The identical organism or identical probiotic may be good for somebody and might be dangerous for an additional particular person. And that’s the most important studying now we have had within the final six years.

Katie: Yeah, I like that you simply introduced up the fecal microbiota switch as nicely. I’ve seen a few of the science on this and… you understand, caveat, this isn’t one thing to aim at residence nevertheless it’s fairly wonderful what they’re conducting in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you possibly can accomplish with out having to go to that excessive if you understand what you’re working with. And for the final two years, I’ve been saying, you understand, early on in well being and wellness, I might discover out info, learn research and be so excited and write about it, and I’ve realized an increasing number of during the last 15 years all the things is so personalised and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You already know, I can let you know what I did nevertheless it’s not gonna work the identical for you. It may be an thought with the start line nevertheless it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”

Which is why I like now an increasing number of entry to those at-home testing whether or not it’s issues like Viome, even now blood testing obtainable at residence, genetic testing simply so we are able to have extra info and entry. And I’ve mentioned so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that permit us be more practical at that may actually, actually make a distinction. So, let’s speak a bit bit extra in regards to the personalization side of this as a result of I additionally am curious…you understand, I do know you mentioned all the things is so totally different. What’s good for one particular person may be not for an additional. Are there any issues which are type of universally unhealthy that you simply’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross checklist, however I’m curious what you’re seeing within the information.

Naveen: Yeah. So to begin with, it’s actually fascinating. I believe you phrased it accurately. There is no such thing as a such factor as common wholesome meals. And meaning there isn’t a such factor that’s good for everybody. Which means the identical meals may be good for you or unhealthy for somebody. Nonetheless, there are some common unhealthy issues that you could know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There is no such thing as a one who says, “The sugar is sweet for me, proper.” In order that’s really having a fried, you understand, fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming lots of sugar, it’s simply unhealthy for everybody. Nonetheless, what we discover most fascinating is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I believe lots of the people who find themselves listening to it, I would like individuals to know the distinction between a DNA which is static. So when individuals do their DNA check, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely happening in your physique. Which means…if, Katie, you permit me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.

So, each a part of our physique is an identical DNA. Which means you have a look at my hair, you have a look at my eyes, you have a look at my enamel, you have a look at my nails, you have a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can grow to be eye, identical DNA can grow to be nail, identical DNA can grow to be pores and skin, identical DNA can grow to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you might be writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each potential factor that may occur. And that’s one factor.

So, what we do at Viome, Katie, is we have a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in direction of the tip. As soon as we perceive all that’s happening, we’re capable of then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so it is best to lower it down, proper.”

We will let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s really not good for you when you could have excessive uric acid manufacturing. So don’t take vitamin B3 you probably have excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people suppose in some way taking NAD or NR, and NMN which is precursor to NAD is definitely enhance your longevity. It’s true for some individuals it might do this, however for others it really will hurt you when you could have excessive mobile senescence, or when you could have excessive inflammatory exercise. You don’t need to be taking extra NAD as a result of that’s gonna enhance the mitochondrial biogenesis that’s going to extend extra free radicals, gonna enhance excessive mobile senescence, proper.

So, the thought actually is that it’s a must to study what is occurring earlier than you deal with your physique like a black field. And I believe you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who have to know what is occurring in our physique as a result of our major care physician…I don’t find out about you, Katie. Once I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the ailing, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t have to…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or in case you had any kind of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary drawback that our healthcare system has is that our medical industrial advanced, everybody makes cash once we are sick and nobody makes cash once we are wholesome. And so, we determined to vary that. In my world of the longer term, Katie, we consider that…I believe similar to you simply mentioned, the way forward for healthcare goes to be delivered at residence, not on the hospitals.

And the medicines of the longer term are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I might say in case you look again at COVID 10 years from now, it is going to be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.

Katie: Completely. I believe so many good silver linings and instructing moments in COVID and other people spent extra time at residence and with their households cooking dinner at residence. There have been lots of nice outcomes, as exhausting because it was for many individuals. I believe we are able to give attention to these positives. And I like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a bit bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some massive advances since then. So, speak about type of the snapshot of what Viome is testing after which how individuals are making adjustments based mostly on that and what they’re seeing.

Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good nevertheless it didn’t inform us how these intestine adjustments had been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence check that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t should go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now have a look at each your intestine well being and your human host and capable of now let you know what’s your organic age. And that tells you not solely, you understand, how nicely or how poorly your physique is ageing in comparison with your chronological age.

So, to offer you an thought, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the degree once I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than in reality I had once I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Which means how nicely are you protected in opposition to in case you had been to catch flu or chilly or any kind of pathogen, how nicely your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you the way nicely your cells are capable of endure the issues which are happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing unit. How nicely the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.

And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the way in which from high of your tube, your saliva, your stool and blood, all three on the identical time. And by that, we’re additionally gonna be capable to present you some extra insights resembling your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna be capable to present you your oral well being resembling your gum well being, your enamel well being and all of the gum, you understand…leaky gum as an alternative of simply leaky intestine. We’ll be capable to present you the way nicely your boundaries of your gums are performing in order that microbes will not be going into your blood.

And different factor we do now which we didn’t do till a couple of 12 months in the past is once you do a check, not solely you get your deep perception what’s occurring in your physique and never simply let you know listed here are the meals which are good for you and right here is why. Listed below are the meals it is best to keep away from and why. We used to let you know listed here are the dietary supplements it is best to take. Now we transcend that, Katie. We’re capable of let you know you solely want 22 milligram of berberine on daily basis. You want 17 milligram of elderberry on daily basis. You want 79 milligram amylase on daily basis. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.

There is no such thing as a premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the way in which, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we alter your dietary supplements on the identical time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of alter your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.

Different issues that I’m actually, actually enthusiastic about…and now we have not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a client you’ll be capable to spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable to let you know you probably have any oral most cancers or throat most cancers. After which we’ll be capable to really join you with a physician to have the ability to do one thing about it. So, if you’re above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable to really at residence do a check and truly know that you simply’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.

Katie: Yeah. That is so leading edge and I believe simply to spotlight what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive expertise. And since you’ve now examined 1000’s and 1000’s, in all probability tons of of 1000’s of individuals, then the algorithm has entry to all this info so it may proceed to get an increasing number of specialised and direct with the suggestions and study your personal physique over time. So, you’re getting this type of ongoing, correct image which I believe is so fascinating.

Naveen: Yeah. So, Katie, now we have analyzed over 350,000 samples already. And that has given us this…you understand, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that now we have analyzed and so they contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one who joins profit themselves and advantages the humanity on the identical time as a result of now the extra we study, the higher suggestions we are able to make for everybody. So, earlier than we simply solely might have a look at your stool. Now we have a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the following factor will likely be with urine. After which we’re gonna begin to have a look at different biomarkers in your physique. So, our suggestions get an increasing number of exact as we study an increasing number of in regards to the human physique. And our actual hope is, you understand, in my lifetime we’ll be capable to perceive what causes the onset of a continual illness and what causes them to progress and to have the ability to forestall them from occurring within the first place, to diagnose them early after they really do occur, and to provide you with a remedy for these illnesses. Not merely handle them however to remedy them as soon as for all for every particular person. And that’s going to be the last word objective of our life.

Katie: And I like that you simply introduced up the interplay of all of the totally different microbiomes throughout the physique as nicely and the way you’re all of those, as a result of a few of my early analysis was in oral well being and studying as an illustration that strep mutants and the micro organism that trigger gingivitis don’t each exist on the identical time. And it’s because now we have an oral microbiome. And if it will get out of steadiness in a single route or the opposite, you’re gonna find yourself with these issues. However the reply will not be sterilizing your mouth and killing all micro organism similar to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you mentioned, you’re these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to talk along with her about that.

However I believe, like we talked about at first, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra type of intricate information we are able to get to make enhancements over time and naturally there can be a most cancers connection right here. You already know, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And this can be a manner of…as a result of even inside a person, in case you’re a metabolic illness, you’re , “Okay, we have to get blood sugar in examine. We have to get blood stress in examine. We have to get weight problems measures in examine.” However the way in which to do this’s gonna be totally different for each single particular person.

Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s brought on…continual irritation is a root explanation for continual illnesses. Nonetheless, what causes the irritation in our physique is totally different for every particular person. So though it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, you understand…has this firm known as Evvy, E-V-V-Y, which seems on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single lady ought to do this as a result of that’s actually…goes to be…you understand, plenty of girls undergo via lots of the illnesses that we as males would by no means perceive. And that to some extent is, you understand, largely reproductive organ and lots of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm start, within the well being of the infant and all of the issues that you simply talked about because the child goes via the start canal. All of the issues that come out in reality are contributory from the vaginal microbiome. So, my excessive suggestion…once more, I’m biased. I believe each lady must be doing the Evvy check, proper.

Now, coming again to the belongings you talked about that, you understand, human well being is advanced however as soon as we perceive biochemical degree what’s going on, that’s the rationale as an alternative of organisms and as an alternative of DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Trying on the entire physique. And I believe, Katie, I wanna level out that the merchandise that you simply construct for oral well being are a few of the greatest merchandise as a result of, to me, what’s the largest gamechanger is individuals thought the organisms had been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t do this. Once you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, you understand, to individuals when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too massive to go down our esophagus, proper. It was really was once you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.

So, the principle factor is that we have to permit the oral microbiome to predigest the feed so your small gut can now take in the vitamins which are already predigested. So, if you find yourself…so two issues it’s good to take into consideration right here. And one is if you find yourself careworn and you might be consuming your meals, it doesn’t get correctly digested and right here is why. If you find yourself careworn, you might be in a combat or flight response. And the primary factor that occurs once you’re in combat or flight response is your digestive system shuts down. Bear in mind why it was designed. Once you’re operating away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And in case you grew to become lunch for another person, it didn’t matter. And in case you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you could possibly digest your meals.

Once you come from work and you might be careworn, what will we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you need to carry your physique from sympathetic mode into parasympathetic mode. Do away with combat or flight response. By taking the deep breath, by doing the gratitude, what you might be doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy strategies we realized within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you might not know that my mother and pop and our faith, they don’t eat after sundown. And I at all times marvel why would that be. And it seems as a result of it’s good to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, in reality telling that, you understand…and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.

And I wanna come again to the oral merchandise. I believe individuals must be actually interested by oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you understand, probiotics. And the merchandise, a few of the merchandise that you’ve, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to start out concentrate as a result of that’s the primary. Your mouth really is the start of your digestive tract. It’s not merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.

Katie: I completely agree. I believe very multifaceted however begin with the mouth is so vital. And I like a few the belongings you simply talked about about why we don’t digest meals if we’re careworn and we all know, in fact, that People stay in a continual state of stress typically. And one factor I’ve grow to be keen on…you understand, there’s a purpose many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you possibly can merely do respiratory workout routines. Do some field respiratory to calm your nervous system. I like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice once I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I observed once I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you may be therapeutic and your physique can get into autophagy and you may allocate assets to all of the pure processes the physique has in-built to maintain us wholesome.

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And I additionally wanna piggyback on what you mentioned about the identical purpose we don’t wanna kill our oral microbiome is similar purpose we don’t wanna kill our intestine micro organism as nicely however I nonetheless see individuals type of hopping on the bandwagon of those actually harsh cleanses or in fact individuals typically take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh influence on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine concern associated to actually type of killing a few of these good micro organism. Clearly, Viome helps with this however type of, like, what may be accomplished? How can we assist repair it?

Naveen: So, very first thing is, you understand, earlier than you go begin taking lots of issues is to know, what’s the state of your intestine micro organism? So do a Viome check, perceive the place it stands. And then you definitely begin to have a look at what you…you understand, we let you know what are the meals it is best to eat. And once more, taking lots of the fermented meals particularly once you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues must be diversification. So as an alternative of simply taking one kind of probiotics, you have to be taking kombucha, the kimchi, the…you understand, all of the fermented meals you possibly can presumably get your fingers on. So, whether or not it’s a yogurt or, you understand, at the very least oat milk yogurt in case you can. I imply, I’m an enormous fan that I believe dairy…in reality for lots of the individuals, dairy is the large drawback. Now I’m not saying it’s for everybody however lots of the individuals, dairy might be an enormous drawback. And the mammalian merchandise really might be an enormous drawback for some individuals and never for others.

So, I’m not the one who is preaching veganism right here in any respect. What I’m saying is know what is sweet for you. There are lots of people who can eat pink meat for all of their life and stay to be 100, and the rationale for that’s pink meat incorporates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the pink meat that causes the center illness. It’s the byproduct of how the pink meat is digested in some folks that produce TMA. So, in case your TMA manufacturing is low, it is best to eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and entire class of meals.

One other factor that we realized…we revealed a paper having analyzed over 100,000 individuals at the moment on ageing. And what we discovered, Katie, that you could be discover actually fascinating is individuals who had been on these fad diets like, you understand, keto food plan or paleo food plan had been the worst offender of their organic age. The individuals who had been on keto food plan in reality had been three to 5 years older than their chronological age and the identical is true for paleo food plan. It seems that people who find themselves on balanced food plan, meaning they had been consuming their carbs however not loads however they had been consuming their regular carbs, they had been consuming their protein, they had been consuming their fats and so they had been consuming the protein, they had been far more balanced, had been really higher off biologically than reducing out the entire nutrient group fully.

Katie: That is smart, that we want the range. And I’ve realized an increasing number of as nicely that I believe the simplistic model all of us realized, hopefully realized at school was about simply type of energy in, energy out. And I’ve heard it mentioned, you understand, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and vital than that.

And what’s subsequent for Viome? I’m curious as a result of I do know you’re continuously doing analysis right here, and such as you mentioned, your objective is to sort out continual illness in its entirety. So, what’s within the pipeline for you guys?

Naveen: Truly, I discussed that subsequent check we’re launching in June is a full physique intelligence. We’re launching a most cancers detect check. And we’re making our dietary supplements and probiotics an increasing number of exact for each particular person since we make it for every particular person. We’re, you understand, attempting to do extra checks now and our objective is to launch within the subsequent six months one other check which is gonna be extra, like, a proteomics check as a result of the issues we can’t see within the blood as a result of they’re produced someplace else. So, can we measure issues, you understand, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict you probably have a leaky intestine by LBP, by CRP which really is completed within the liver? So, we’re going to have the ability to really measure extra issues along with simply those that we’re measuring, and the extra info we are able to study, the higher suggestions we make. So, our hope is to proceed to launch these checks that give us higher and higher insights and meaning we are able to make an increasing number of exact suggestion for every particular person.

Final objective actually is to know…as you say, the human physique is a chemistry lab. We now have mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to know that the gene expression tells you what biochemistry is happening within the physique. And that’s a purpose…and in reality, Viome is the one firm that does have a look at the gene expression as a result of there isn’t a different firm that has this expertise. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense challenge. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ value of assets to develop this expertise. Sadly, we had been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to generate profits, we might not have been capable of license this expertise, proper.

So, the actual fact immediately we’re merely targeted on making each single particular person be higher. You already know, our mission on day one was what if we might perceive the human biology at a molecular degree so we are able to forestall, diagnose early and remedy these continual illnesses together with most cancers and ageing? And I believe lots of the individuals who have heard you and I speak up to now, you understand that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I might have probably saved my dad. And, you understand, having watched him undergo that ache or struggling via most cancers I noticed that though I couldn’t save him, I might dedicate my life to saving everybody else. And that will likely be my manner of letting him know that, you understand, I’m so pleased with what he…how he raised us as a toddler and giving us all the things now we have so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or despair, nervousness or most cancers.

And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I had been to make a prediction immediately, I’ll let you know inside a decade I believe we are going to do away with most cancers from the human physique.

Katie: That’s an enormous declare and I hope we’re on observe for that as nicely. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the continual stress of the final couple of years will not be serving to that drawback. So, I’m grateful that there are assets such as you, and I’ve accomplished Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be certain that…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. Yow will discover the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a guide or numerous books which have profoundly influenced your life. And if that’s the case, what they’re and why?

Naveen: Yeah, so the guide that basically influenced me…there’s a guide by Clayton Christensen, you understand. I like the person and I noticed him earlier than he died. The guide he wrote, “How Will You Measure Your Life?” And to me it was such a profound guide which tells you that it’s a must to be 100% sincere. You can’t be 99% sincere as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll at all times be another excuse to make an exception. And so, it’s a must to focus your self to by no means, ever compromise in your rules that you simply stand for. And that was simply completely a fabulous guide I learn.

You already know, the guide that additionally…I imply, clearly I wrote a guide known as “Moonshots” that’s actually about making a mindset of abundance relatively than a mindset of shortage. And the basic perception that I’ve is that there’s nothing that people will not be able to doing if we really get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they will’t. That after you consider one thing is unattainable, it turns into unattainable for you and nobody else. And so, you might be fully in management. The one factor you possibly can’t do is what you possibly can’t think about. The whole lot else is feasible.

Katie: I like that. I do know you and I each increase our youngsters with that mindset and yours are older and doing wonderful issues out on the earth already and mine are at first phases of that. And lastly, what parting recommendation would you want to depart with the viewers immediately? May very well be associated to one thing we’ve talked about or fully unrelated.

Naveen: I might say dream so massive that folks suppose you’re loopy. Which means by no means let somebody let you know that you could’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self will not be about being self-conceited. Loving your self is about not on the lookout for another person’s approval to do the issues that imply loads to you. Observe your coronary heart, observe your intestine, hearken to your intestine and observe what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever suppose it’s work. I stand up on daily basis at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, in case you’re not leaping out of the mattress, it is best to give up what you might be doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to unravel that drawback.

And, Katie, I simply need to reiterate, I met your children and I do know I keep in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to truly transfer this humanity ahead. You’re elevating these youngsters with the mindset that all the things they need to do, they will. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it lots of instances. Like, once we increase our youngsters, we inform them, “Our love for you is unconditional however our approval will not be.” And what meaning is solely is that we’ll at all times love you, we’ll at all times be there for you, however I’m not gonna let you know I’m pleased with you except you do issues that make us pleased with you. And that’s actually the factor about telling the youngsters that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It is going to be measured by what number of lives they enhance. And the humility is an indication of success as a result of in case you nonetheless have iota of vanity left in you, meaning you’re nonetheless attempting to show one thing to your self or another person. And humility tells you not have to do this, proper. And that could be a true signal of success. And all I can say is I’m so pleased with each certainly one of your youngsters, Katie. And I can’t await them to develop up and truly do issues that can make our youngsters’s and grandchildren’s life higher.

Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children on daily basis, “I like you unconditionally and there’s nothing you ever should do to earn my love and there’s nothing you could possibly ever do that may take away from my love.” However you’re proper. Additionally, I would like that, like, their satisfaction to come back from inside, like…and I inform them typically, “You will need to really feel actually pleased with how exhausting you labored and you should…” As a result of I would like them to have that inside them and that self-love.

And that is why I’m so grateful each single day that I get to speak to our viewers that’s listening immediately of mothers, as a result of I believe mothers have such a tremendous distinctive skill to actually shift the way forward for humanity by how we dad or mum our youngsters and by serving to type these future leaders. And for individuals who aren’t already acquainted with you, I might encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these wonderful issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as nicely. So very grateful in your entire household and for all that every one of you might be doing on the earth and in your time immediately. I understand how busy you might be and I’m so grateful you took the time to be right here.

Naveen: Oh, Katie, it’s at all times an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.

Katie: And thanks, as at all times, to all of you for listening and sharing your most useful assets, your time, your vitality, and your consideration with us immediately. We’re each so grateful that you simply did. And I hope that you’ll be a part of me once more on the following episode of the “Wellness Mama” podcast.

 

When you’re having fun with these interviews, would you please take two minutes to depart a score or evaluate on iTunes for me? Doing this helps extra individuals to seek out the podcast, which suggests much more mothers and households may benefit from the knowledge. I actually respect your time, and thanks as at all times for listening.

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